The requisition form should always be read during embedding for proper orientation. The embedding should be done according to the type of tissue.
![synergy auto lab synergy auto lab](https://mlnxb67kbptn.i.optimole.com/iMmMJ0k-EEuKV9tG/w:auto/h:auto/q:auto/https://www.synergyconsultants.com/wp-content/uploads/2021/05/lab-grown-meat.jpg)
At the time of grossing, mark with India ink may be put on the side of the tissue opposite that to be cut. Incorrect placement of tissues may result in diagnostically important tissue elements being missed or damaged during microtomy.ĭuring embedding it is important to orient the tissue in a way that will provide the best information to the pathologist. Correct orientation of tissue in a mold is the most important step in embedding.
![synergy auto lab synergy auto lab](https://live.staticflickr.com/8377/8582179445_440bb55619_c.jpg)
This “embedding” process is very important, because the tissues must be aligned, or oriented, properly in the block of paraffin.ĭuring embedding the orientation of tissue is important. Tissues that come off the tissue processor are still in the cassettes and must be manually put into the blocks by a technician who must pick the tissues out of the cassette and pour molten paraffin over them. Improper orientation causes addition rework due to re-embedding and could lead to loss of tissue samples at microtomy that jeopardizes diagnosis. The embedding technician must open each cassette taking care not to lose the specimen, properly orientate the specimen into the embedding mold, fill with paraffin and allow the block to cool.
#SYNERGY AUTO LAB MANUAL#
Manual embedding introduces multiple risk factors such as loss of tissue samples, orientation errors and cross contamination. Once the processing is complete the responsibility of proper orientation falls on the technician performing the manual embedding. Using these techniques might increase reagent carryover during the continuous rapid tissue processing which reduces reagent usage life and increases reagent replacement frequency, thus driving an increase is processing cost. The person performing the grossing must take care not to submit tissue too large and for smaller tissues often uses micromesh cassettes, tissue bags, biopsy sponges or wraps the tissue before place the specimen into the cassette. The pathologist or pathologist assistant describes the tissue, performs gross dissection and at times inks the tissue for orientation. Historically embedding was performed manually. Synergy auto-embedding reduces common embedding errors such as orientation errors and loss of tissue samples. With the Synergy auto-embedding system tissues are orientated and secure from grossing to sectioning without additional handling at the embedding station minimizing the loss of tissue samples or orientation errors. Re-embedding and tissue loss are obstacles every lab would like to avoid. The Synergy auto-embedding system offers specimen integrity. Once the paraffin is solidified the base mold is removed and the block is ready to be transferred to the microtome for sectioning. Once the processing is completed the paraffin filled mold is removed from the Synergy rack, placed on a cold plate and allowed to solidify. The assembled mold and cassette are then placed into the Synergy rack and loaded onto the continuous rapid tissue processor. Once the pad is in place and standard tissue cassette is clicked onto the mold. The consumables consist of a disposable base mold and a special orientation pad, no special cassettes are required.ĭuring the grossing phase the specimen is placed into the Synergy mold and the orientation pad is placed on top of the tissue. The Synergy auto-embedding system consist of a specially designed rack and unique consumables that allow the user to process up to 45 specimens per continuous rapid processing protocol. The Synergy auto-embedding Systems provide high quality and safe tissue processing, consistent clean blocks, improved turnaround time and all-important same-day diagnosis of cancer specimens. All kind of tissues and dimensions can be rapidly processed and auto-embedded with this method.
![synergy auto lab synergy auto lab](https://images.squarespace-cdn.com/content/v1/5f29949def6bf9537f1d4312/1596586376077-7I4T7UDW9FNID4KKOOA3/Synergy+Auto+Lab++android-chrome-512x512.png)
Thanks to the dedicated rack and consumables, the same processor unit can achieve continuous rapid tissue processing while auto-embedding, there is no need for additional equipment. This method is applied to Milestone continuous rapid tissue processors, Pathos Delta, Logos and Magnus. EP 2 439 510 A1) method to auto-embed tissues as part of the continuous rapid tissue processing protocol. The Milestone Synergy system allows for ALL-IN-ONE Continuous Rapid Tissue Processing and Auto-Embedding.